CMBN scientists have recently published a paper in the journal PLoS Genetics on two modes of expansion of CAG repeats in Huntington's disease mice.

Møllersen L, Rowe AD, Larsen E, Rognes T, Klungland A
Continuous and periodic expansion of CAG repeats in Huntington’s disease R6/1 mice
PLoS Genet, 6 (12), e1001242

CMBN scientists have recently published a paper in the journal Blood on degradation of an important oncoprotein in leukemia. The project is a collaboration between the research groups of Stig Ove Bøe and Anne Simonsen.

Isakson P, Bjørås M, Bøe SO, Simonsen A
Autophagy contributes to therapy-induced degradation of the PML/RARA oncoprotein
Blood (in press)

The project is featured as the Monthly research project by the Norwegian Cancer Society:

Celler spiser kreftfremkallende komponenter

CMBN scientists have recently published a paper on the evolution of pathogenic Neisseria in the journal PLoS Pathogens:

Aspholm M, Aas FE, Harrison OB, Quinn D, Vik Å, Viburiene R, Tønjum T, Moir J, Maiden MCJ, Koomey M (2010)
Structural Alterations in a Component of Cytochrome c Oxidase and Molecular Evolution of Pathogenic Neisseria in Humans
PLoS Pathogens, 6 (8), e1001055

The paper is highlighted as Featured Research in PLoS Pathogens:

Aspholm, Aas and colleagues describe two successive alterations in a single gene that can be linked first to all species within the genus Neisseria and then the species N. meningitidis. Their findings provide a dramatic example of how rare changes in core metabolic proteins can be connected to significant macroevolutionary shifts and have significant implications for the evolution of related bacterial species within a single host.

Tuesday 11 May 2010 at 1400
In the Art hall, Mezzanine, Radisson Blu Plaza Hotel, Sonja Henies Plass 3, Oslo

Program

Moderator Jon Storm-Mathisen, Professor, Dep. of Anatomy, University of Oslo

Programme as PDF

CMBN scientist Hua Hu has recently published a paper on signals in interneuron dendrites in Science:

Hu H, Martina M, Jonas P (2010)
Dendritic mechanisms underlying rapid synaptic activation of fast-spiking hippocampal interneurons
Science, 327 (5961), 52-8
PubMed 19965717