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News 2007

CMBN scientist Vidar Gundersen receives Monrad-Krohn's Prize 2007
Announced 6 December 2007
CMBN scientist Vidar Gundersen has received Monrad-Krohn's Prize for 2007. The prize, established 1933 by professor of neurology, GH Monrad-Krohn, is awarded by the Medical Faculty of the University of Oslo for outstanding neurological research. The award was presented by Professor Rolf Nyberg-Hansen at the annual meeting of the Norwegian Neurological Society, on 30 November 2007. Dr. Gundersen gave his prize lecture on 'Amino acids as signal transmitters at CNS synapses'.   Vidar Gundersen receives Monrad Khrohn's prize 2007 by  Rolf Nyberg-Hansen
Postdoctoral/research fellow position available
Announced 10 July 2007

A post-doctoral / research fellow position is available at the Institute of Clinical Biochemistry and Centre of Molecular Biology and Neuroscience, University of Oslo.

Please see the full announcement. Application deadline: 20 Nov 2007.

Nordic EMBL partnership signed
Announced 22 October 2007

The Nordic EMBL partnership contract with the three Institutes of Molecular Medicine located in Umeå, Helsinki and Oslo has been signed.

UiO får molekylærmedisinsk senter i meisterklassen
UNIFORUM nett no, 3 October 2007

Northern exposure for EMBL
Nature, 447, 504

Training position available
Announced 10 July 2007

A training position in neuroanatomy / neuroinformatics is available at NeSys. Application deadline 5 August 2007.

Midterm evaluation of Nordic Centres of Excellence in Molecular Medicine
Announced 18 June 2007

The Nordic Centres of Excellence (NCoE) in Molecular Medicine has been through a midterm evaluation. Two of the centres, Centre for Water Imbalance Related Disorders (WIRED) and Centre for Molecular Mechanisms of Neurogenerative Diseases, involves scientists from CMBN. All the evaluations were favourable.

Chaudhry awarded outstanding young investigator grant
Announced 31 May 2007

Professor Farrukh A. Chaudry at the Biotechnology Centre of Oslo, University of Oslo, have been awarded an Outstanding Young Investigator grant ("Yngre Fremragende Forskere" - YFF) from the Research Council of Norway with the project "Physiological and pathological impacts of glutamine transporters". Chaudhry is also a CMBN associated guest professor.

20 nye yngre fremragende forskere, Research Council of Norway, 31 May 2007.

CMBN enters Nordic EMBL partnership
Announced 24 May 2007

The European Molecular Biology Laboratory (EMBL) has extended a Nordic EMBL partnership with three Institutes of Molecular Medicine located in Umeå, Helsinki and Oslo. CMBN is associated with the new Institute of Molecular Medicine in Oslo.

Hannah Hoag (2007)
Northern exposure for EMBL
Nature, 447, 504

Neuroscience publishes special issue on Genome Dynamics and DNA Repair in the CNS
Announced 27 April 2007

The journal Neuroscience has just published a special issue on Genome Dynamics and DNA Repair in the CNS. The issue contains many contributions from CMBN scientists and colleagues. Editors are Vilhelm A Bohr, Ole Petter Ottersen and Tone Tønjum.

Bohr VA, Ottersen OP and Tønjum T (eds.) (2007)
Special Issue: Genome Dynamics and DNA Repair in the CNS
Neuroscience, 145 (4), 1183-1448

Neuroscience, special issue
Publication in Nature on the link between Huntington's disease and DNA repair
Announced 24 April 2007

Artistic rendering of a broken DNA helix emanating from a mouse nerve cell. Researchers recently uncovered evidence that faulty DNA repair may be to blame for the onset of Huntington's disease symptoms. (Credit: Cynthia McMurray)Cynthia McMurray's group at the Mayo Clinic, Rochester, MA, USA, and collaborators at NIH and CMBN have published a study on how DNA repair of oxidative damage is involved in Huntington's disease. The paper explains the role of the 8-oxoguanine-DNA glycosylase (OGG1) enzyme in initiation of age-dependent CAG trinucleotide expansion associated with Huntington's disease that occurs in somatic cells.

Kovtun IV, Liu Y, Bjørås M, Klungland A, Wilson, SH & McMurray CT (2007)
OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells
Nature (in press)

See also:
Clue to Huntington's is found, New York Times (reg. req.), 24 April 2007
Faulty DNA Repair Linked To Huntington's Disease Onset, Science Daily, 23 April 2007
Study Links Faulty DNA Repair to Huntington’s Disease Onset, NIH press rel, 22 April 2007
Study identifies trigger for Huntington's disease, Reuters, 22 April 2007

Publication in EMBO Journal on the structural basis for excision of certain methylated bases from DNA
Announced 9 April 2007

The structural basis of how two particular types of methylated bases in DNA are removed has recently been published in the EMBO Journal by CMBN researchers and collaborators.

Leiros I, Nabong MP, Grøsvik K, Ringvoll J, Haugland GT, Uldal L, Reite K, Olsbu IK, Knævelsrud I, Moe E, Andersen OA, Birkeland NK, Ruoff P, Klungland A, Bjelland S (2007)
Structural basis for enzymatic excision of N(1)-methyladenine and N(3)-methylcytosine from DNA
EMBO J (in press)

CMBN annual report 2006
Announced 9 April 2007

The CMBN annual report 2006 is now available. CMBN annual report 2006

CMBN chosen as host for National Neuroinformatics Node
Announced 9 April 2007

The Research Council of Norway has appointed CMBN as host institution for the Norwegian Node of the newly established International Neuroinformatics Coordinating Facility (INCF). The node is lead by Gaute Einevoll (left), senior researcher at CMBN and professor at the Norwegian University of Life Sciences, and Johan Storm (right), professor and group leader at CMBN. The node will support national neuroinformatics projects, meetings and courses, and map neuroinformatics activities.

Gaute Einevoll Johan F Storm

Publication in Oncogene on the Cockayne Syndrome B (CSB) gene
Announced 20 March 2007

CMBN researchers and collaborators in Germany have recently published in Oncogene data from a study that indicates that the Cockayne syndrome B (CSB) gene is involved in the inhibition of mutations caused by spontaneous oxidative DNA base damage.

Trapp C, Reite K, Klungland A, Epe B (2007)
Deficiency of the Cockayne syndrome B (CSB) gene aggravates the genomic instability caused by endogenous oxidative DNA base damage in mice
Oncogene (in press)

Job available
Announced 16 March 2007

There is a job available in the mitochondria group at CMBN.

Publication in Nature Neuroscience on the function of glial glutamate release
Announced 27 February 2007

CMBN researchers Linda H Bergersen and Vidar Gundersen publish in Nature Neuroscience on the function of glial glutamate release. Synaptic activation of granule cells by the perforant path (the main input to the hippocampus) is enhanced by glutamate exocytosed from astrocytes onto presynaptic NR2B containing receptors. The mechanism is triggered by neuronal activity dependent stimulation of P2Y1 purine receptors on the astrocytes.

Vidar Gundersen Linda H Bergersen

Jourdain P1, Bergersen LH1, Bhaukaurally K1, Bezzi P, Santello M, Domercq M, Matute C, Tonello F, Gundersen V2, Volterra A2 (2007)
Glutamate exocytosis from astrocytes controls synaptic strength
Nat Neurosci, 10, 331-339
1contributed equally; 2corresponding authors

See also News and Views.

Publication in Journal of Neuroscience on subcellular distribution of M-channels
Announced 27 February 2007

Hu H, Vervaeke K, Storm JF (2007)
M-channels (Kv7/KCNQ channels) that regulate synaptic integration, excitability, and spike pattern of CA1 pyramidal cells are located in the perisomatic region
J Neurosci, 27, 1853-67

Two jobs available
Announced 26 February 2007

There are two jobs available in the mitochondria and bioinformatics groups at CMBN.

Centre for Molecular Biology and Neuroscience (CMBN)
PO Box 1105 Blindern, NO-0317 Oslo, Norway. Tel: +47 22851528. Fax: +47 22851488