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The Bioinformatics group uses computational methods to analyse genome sequences, amino acid sequences, and gene expression data, both to identify new genes of interest and to determine their structure, function and role in the cell. Advanced computational tools are both being used and developed. The group is also creating databases and web sites with our tools and generated data. We are involved in many collaborative projects with different research groups.
Huge amounts of molecular biology data is being generated from a range of different technologies. New technologies allow extensive sequencing to be carried out to analyse sequence variation, transcription, epigenetics and other phenomena. Complete genome sequences from more than a thousand organisms as well as data from large-scale protein structure determination projects are also publicly available. The main challenge in computational biology is to integrate and make sense of all of this data.
We have developed the fastest implementation of the important Smith-Waterman local sequence alignment algorithm (BMC Bioinformatics, 2011). We have also discovered an important mutation in the AP endonuclease in lab strains of S.pombe (DNA repair, 2011). Furthermore, we have characterized the role of specific domains in the protein structure of PCSK9 in degradation of the LDL receptor (J Lipid Res 2011; BBRC, 2011) and contributed to the characterization of a PSC susceptibility locus (Nat Genet 2011).
Centre for Molecular Biology and Neuroscience
Mob: +47 90755587
Structural model of the PCSK9 protein that mediates degradation of the low density lipoprotein (LDL) receptors. The important Ser462 residue that reduces secretion when mutated is indicated. From Cameron et al. (2009).
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|Centre for Molecular Biology and Neuroscience (CMBN)
PO Box 1105 Blindern, NO-0317 Oslo, Norway. Tel: +47 22851528. Fax: +47 22851488