University of Oslo Rikshospitalet
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The Centre for Molecular Biology and Neuroscience (CMBN) (Senter for molekylærbiologi og nevrovitenskap) is a Norwegian Centre of Excellence at the University of Oslo and Rikshospitalet, Oslo University Hospital. CMBN shall take on a leading role in elucidating the role of DNA repair and genome maintenance mechanisms in preventing neurological disease and brain ageing.

Recent news and upcoming events
Nina Therese Solberg's trial lecture and PhD defense
Announced 31 August 2010

Nina Therese Solberg will give her trial lecture with the title

Molecular regulation of the neurogenic niche in the adult brain: Implications for health and disease

on Tuesday 31 August 2010 at 1515, in Auditorium 2 (Red), Rikshospitalet.

She will defend her PhD thesis with the title

Aspects of canonical Wnt signaling in the developing mouse forebrain

on Wednesday 1 September 2010 at 1015, in Auditorium 2 (Red), Rikshospitalet.

Johanne Egge Rinholm's trial lecture and PhD defense
Announced 30 August 2010

Johanne Egge Rinholm   Johanne Egge Rinholm will give her trial lecture with the title

Mitochondrial dysfunction in neurological diseases

on Monday 30 August 2010 at 1600, in new auditorium 13, Domus Medica, University of Oslo.

She will defend her PhD thesis with the title

Energy Supply and Signalling in Grey and White Matter Structures of the Brain

on Tuesday 31 August 2010 at 1000, in new auditorium 13, Domus Medica, University of Oslo.

Publication in PLoS Pathogens by CMBN scientists
Announced 24 August 2010

CMBN scientists have recently published a paper on the evolution of pathogenic Neisseria in the journal PLoS Pathogens:

Aspholm M, Aas FE, Harrison OB, Quinn D, Vik Å, Viburiene R, Tønjum T, Moir J, Maiden MCJ, Koomey M (2010)
Structural Alterations in a Component of Cytochrome c Oxidase and Molecular Evolution of Pathogenic Neisseria in Humans
PLoS Pathogens, 6 (8), e1001055

The paper is highlighted as Featured Research in PLoS Pathogens:

Aspholm, Aas and colleagues describe two successive alterations in a single gene that can be linked first to all species within the genus Neisseria and then the species N. meningitidis. Their findings provide a dramatic example of how rare changes in core metabolic proteins can be connected to significant macroevolutionary shifts and have significant implications for the evolution of related bacterial species within a single host.

 

Mini symposium: "Mental Illness: Bipolar Disorder and Depression"
Announced 10 August 2010

CMBN is pleased to announce the following mini symposium:

Mental Illness: Bipolar Disorder and Depression

24 August 2010, at 1400 to 1630
Green auditorium 1, Rikshospitalet, Oslo

Full Programme (PDF)

Media coverage
  Til bunns i hjernens vannkanaler
Forskningsrådet
18 June 2010
Jakten på intelligensgener
Kronikk av Farrukh A. Chaudhry og Joel Glover
Morgenbladet
14 May 2010
Tone Tønjum   Forsker på cocktail mot aldring
VG (print edition, p. 22)
26 February 2010
Elisabeth Larsen

Lovende stamceller
Kronikk av Elisabeth Larsen (PhD, CMBN & Rikshospitalet)
Aftenposten
23 January 2010


Bakterier endrer synet på sex
forskning.no
23 October 2009
Ole Herman Ambur

Bakterier endrer oppfatningen om sex
Apollon
19 October 2009
Nobelprisen i medisin for oppdagelsen av telomerer (MP3)
(Intervju med Magnar Bjørås)
Verdt å vite, NRK Radio P2
6 October 2009
Ida Rosnes   Ryggejente kan knekke kreftkode
Moss Avis
3 August 2009
Åshild Vik   Gonoré, en søt bakterie
Uniforum
20 August 2009
Håpløst urealistisk holdning? Debattinnlegg av Jon Storm-Mathisen
Aftenposten
17 August 2009
Hjernens mysterier   Hjernens mysterier (video)
Lørdagsmag., Nyhetene, TV2
21 March 2009

More media coverage...

Latest publications

Strøm BO, Aden P, Mathisen GH, Lømo J, Davanger S, Paulsen RE
Transfection of chicken cerebellar granule neurons used to study glucocorticoid receptor regulation by nuclear receptor 4A (NR4A)
J Neurosci Methods (in press)
PubMed 20727911

Bohlin J, Snipen L, Cloeckaert A, Lagesen K, Ussery D, Kristoffersen AB, Godfroid J (2010)
Genomic comparisons of Brucella spp. and closely related bacteria using base compositional and proteome based methods
BMC Evol Biol, 10, 249
PubMed 20707916

Bohlin J, Snipen L, Hardy SP, Kristoffersen AB, Lagesen K, Dønsvik T, Skjerve E, Ussery DW (2010)
Analysis of intra-genomic GC content homogeneity within prokaryotes
BMC Genomics, 11, 464
PubMed 20691090

Duri K, Gumbo FZ, Kristiansen KI, Kurewa NE, Mapingure MP, Rusakaniko S, Chirenje MZ, Muller F, Stray-Pedersen B (2010)
Antenatal HIV-1 RNA load and timing of mother to child transmission; a nested case-control study in a resource poor setting
Virol J, 7, 176
PubMed 20678190

Hjornevik T, Schoultz BW, Marton J, Gjerstad J, Drzezga A, Henriksen G, Willoch F (2010)
Spinal long-term potentiation is associated with reduced opioid neurotransmission in the rat brain
Clin Physiol Funct Imaging, 30 (4), 285-93
PubMed 20662879

Boulland JL, Halasi G, Kasumacic N, Glover JC (2010)
Xenotransplantation of human stem cells into the chicken embryo
J Vis Exp (41)
PubMed 20644515

Heuser K, Hoddevik EH, Taubøll E, Gjerstad L, Indahl U, Kaczmarek L, Berg PR, Lien S, Nagelhus EA, Ottersen OP (2010)
Temporal lobe epilepsy and matrix metalloproteinase 9: a tempting relation but negative genetic association
Seizure, 19 (6), 335-8
PubMed 20605480

Görbitz CH, Backe PH (2010)
L-isoleucyl-L-asparagine 1.094-hydrate: a hybrid hydrogen-bonding pattern
Acta Crystallogr C, 66 (Pt 7), o349-52
PubMed 20603563

Malmierca MS, Blackstad TW, Osen KK
Computer-assisted 3-D reconstructions of Golgi-impregnated neurons in the cortical regions of the inferior colliculus of rat
Hear Res (in press)
PubMed 20600744

Kaufmann WA, Kasugai Y, Ferraguti F, Storm JF (2010)
Two distinct pools of large-conductance calcium-activated potassium channels in the somatic plasma membrane of central principal neurons
Neuroscience, 169 (3), 974-86
PubMed 20595025

Centre for Molecular Biology and Neuroscience (CMBN)
PO Box 1105 Blindern, NO-0317 Oslo, Norway. Tel: +47 22851528. Fax: +47 22851488