Mitochondrial Function: Basic Mechanisms and Clinical Aspects

Research seminar (forskerkurs) arranged by CMBN

Thursday 14 - Friday 15 April 2005
Store auditorium, Rikshospitalet

Sign on to the course by email to Den norske lægeforening: koordinatorkontoret.oslo@legeforeningen.no
Application deadline: 1 April 2005

Contact Henriette Haugen, CMBN, by email for more information about the course: henriette.haugen@medisin.uio.no

Scope

The objective of the course is to highlight various aspects of mitochondrial function and visualize the central role that mitochondrial dysfunction plays in many diseases. Mitochondrial dysfunction is characteristic of several neurological diseases, cancer, life style diseases as well as aging in general. Topics presented will cover mitochondrial homeostasis, including mitochondrial DNA replication and repair, oxidative stress, calcium signaling and energy metabolism. Seminar contributors include internationally well-recognized scientist in the field of mitochondrial science.

Program

The program is preliminary as of 13 April 2005. It is subject to changes.

Thursday

8:30-9:00 Registration

Metabolism, Bioenergetics

Chair: Ulrik Malt

9:00 Bjørnar Hassel, Norwegian Defence Research Establishment, Kjeller: “TCA cycle anaplerosis and neurological/psychiatric impairment”

9:40 Rolf K. Berge, Section of Medical Biochemistry, Department of Internal Medicine, Haukeland University Hospital: “Metabolic syndrome in relation to mitochondrial function and PPAR activation”

10:20 Coffee break

10:50 Harald Osmundsen, Institutt for oral biologi, UiO: “Effects of toxins on mitochondrial function”

11:10 Karl Johan Tronstad, Section of Medical Biochemistry, Department of Internal Medicine, Haukeland University Hospital: "Mitochondria and cell proliferation"

11:30 Ola Skjeldal, Department of Paediatrics, Rikshospitalet: ”Genetically inherited mitochondrial syndromes”

11:50 Coffee

Mitochondrial Genetics – implications for diseases

Chair: Arne Klungland

12:10 Laurence Bindoff, Department of Neurology, Haukeland University Hospital:
“Genetic basis for muscle disease”

13:00 Lunch

14:00 Nils-Göran Larsson, Department of Medical Nutrition, Karolinska Instititutet, Novum: “Mouse models for mitochondrial diseases

14:45 Coffee break

Mitochondria in cell signaling, apoptosis

Chair: Ragnhild Paulsen

15:00 Paolo Pinton, Section of General Pathology, Department of Experimental and Diagnostic Medicine, Telethon Center for Cell Imaging and Interdisciplinary Center for the Study of Inflammation, University of Ferrara, Italy: "Mitochondrial Ca²⁺ signals: message of life and death.”

15:45 Thor Willy Ruud Hansen, Section on Neonatology, Rikshospitalet, Oslo “Bilirubin oxidation in brain”

16.30 Reception, cheese and wine “PhD students meet the Speaker”

Friday

Mitochondrial function in microbial pathogenesis

Chair: Tone Tønjum

9:00 Michael Koomey, Centre for Molecular Biology and Neuroscience, University of Oslo: "Targetting of mitochondria by bacterial pathogens"

9:30 Anne Maagaard, Ullevål University Hospital: “Mitochondrial dysfunction and HIV-infection / antiretroviral treatment” .

9:50 Coffee

Mitochondrial DNA - replication and repair

Chair: Kirsten Skarstad

10:10 Aurelio Reyes, Dunn Human Nutrition Unit, Wellcome Trust-Medical Research Council Building, Cambridge, UK: "Ribonucleotides in replicating and non-replicating mitochondrial DNA"

10:55 Rut Valgardsdottir, Istituto di Genetica Molecolare Consiglio Nazionale delle Ricerche, Pavia, Italy: "Mitochondrial helicases"

11:15 Coffee

11:45 Tinna Stevnsner, Århus University, Denmark: "Mitochondrial DNA repair mechanisms and changes with aging"

12:30 Lars Eide, CMBN: “mtDNA alteration in mouse model of the neurodegenerative disorder Cockayne Syndrome”

13:00 Lunch

Mitochondrial DNA evolution

Chair: Torbjørn Rognes

14:00 Erika Hagelberg, Department of Biology, University of Oslo: "Human mitochondrial DNA variation in relation to migrations and selection"

Mitochondrial role in neuronal homeostasis

Chair: Jon Storm-Mathisen

14:40 Ole A. Andreassen, Department of Psychiatry, Ullevål University Hospital and University of Oslo: "Novel treatment regimens for Huntington's disease. Studies of transgenic mouse models implicate mitochondrial dysfunction"

15:20 Ole Petter Ottersen, CMBN, University of Oslo: “Mitochondrial role in glutamate signaling and neuronal homeostasis”

16.00 Concluding remarks

Additional information

The course will give 2 study points for the PhD programme at the University of Oslo, provided that the course exam is completed.

Course exam questions will be made available here. Send your answers as an email attachment to lars.eide@medisin.uio.no by 22 April 2005.

Information about this course from Legeforeningen.