CMBN research seminar (forskerkurs):
Recent advances in Molecular Biology and Neuroscience - Focus on Gaustad Neuroscience Network (GNN)

Monday 4 - Tuesday 5 October 2004
Store auditorium, Rikshospitalet

Deadline for signing on the course: 1 October 2004 to Den norske lægeforening, email koordinatorkontoret.oslo@legeforeningen.no

Information on the course: Peder Heyerdahl Utne, CMBN, email p.h.utne@basalmed.uio.no

Scope

The objective of the course is to highlight recent advances related to molecular biology and neuroscience and the pathogenesis and clinical aspects of neurological disease. Topics addressed will be relevant for neurological disease and pathogenesis, genome instability and stem cell biology. The new information provided is aimed at building an innovative basis for the development of new approaches for the diagnosis and treatment of brain disease and age-related neurological impairment. The course will focus on translational research and on current and planned interactions between the basic and clinical research environments that form the Gaustad Neuroscience Network (GNN).

Program

As of 27 September 2004. The program may be subject to minor changes.

Monday, 4 October

12:00 - 12:30 Registration, coffee

Convenor: Ole Petter Ottersen

12:30 Åge Danielsen, Rikshospitalet: Welcoming address. Stein Evensen, Universitetet i Oslo: Welcoming address.

Introduction to genome instability and neurological disease

12:45 Leif Gjerstad, Nevrologisk avdeling, UiO/RH: Neurological disease today – what are the challenges and what are the opportunities offered by the new technologies?

13:15 Ole Petter Ottersen, CMBN: Basic neurobiology today – methodological advances open new possibilities for research on disease mechanisms

13:45 Erling Seeberg, CMBN: How do defects in DNA repair promote ageing and neurological disease? Prokaryotic models for neurological disease

14:15 Coffee break

Genetics and pathogenesis of neurodegenerative diseases

Convenor: Jon Storm-Mathisen

14:45 Leena Peltonen, National Public Health Institute, Department of Molecular Medicine, and Department of Medical Genetics, University of Helsinki, Finland: Impact of modern genomic tools on insight into neurological diseases. Use of tissue repositories in neurological research - future possibilities and methodological aspects

15:30 Sigbjørn Lien, Cigene: High-throughput SNP analysis and biological function

16:00 Coffee break

Neuroimaging

Convenor: Leif Gjerstad

16:15 Arne Skretting, Radiumhospitalet: PET – Introduction to how it works

16:35 Frode Willoch, Aker sykehus: PET in neuropsychiatry

16:55 Atle Bjørnerud, Radiologisk avdeling, RH: fMRI – mechanisms and possibilities

17:15 Espen Dietrichs, Nevrologisk avd., RH: fMRI in clinical neurology

17:35 Refreshments and discussion

Tuesday, 5 October

Cognitive neuroscience

Convenor: Jon Storm-Mathisen

9:30 Johan Storm, CMBN: Potassium channels in memory functions and ageing

10:00 Ivar Reinvang, Psykologisk institutt, UiO: New aspects of normal and abnormal memory functions

10:30 Coffee break

Neuropharmacology: Molecular aspects of synaptic transmission

11:00 Jon Storm-Mathisen, CMBN: Providing the transmitter: molecular analysis of synthesis, storage and metabolism – possible pathophysiological mechanisms

11:30 Ulrik Malt, Psykosomatisk avdeling, RH: New insights in neuropharmacology of psychiatry

The oedematous brain

Convenor: Leif Gjerstad

12:00 Ola Didrik Saugstad, Barneavdelingen, RH: Hypoxic brain oedema - causes and symptoms)

12:30 Mahmood Amiry-Moghaddam, CMBN: Impact of Aquaporin 4 on brain oedema

13:00 Lunch

Genetics and pathogenesis of neurodegenerative diseases - II

Convenor: Ole Petter Ottersen

13:45 Lars Lannfelt, Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Sweden: Genetics, pathophysiology and future treatment of Alzheimer's disease

14:30 Ola Skjeldal, Barneavdelingen, Rikshospitalet: Genetic syndromes in childhood

Neuro-therapeutic potential of stem cells

15:00 Stefan Krauss, CMBN: Neural stem cells: Overview of stem cell biology and therapeutic potential

15:30 Jon Berg-Johnsen, Nevrokirurgisk avdeling, RH: Stem cells harvested from the ventricular wall – potential clinical use

16:00 Coffee break

Neuroimmunology

16:15 Frode Vartdal, Immunologisk institutt, RH: The impact of neuroimmunology in understanding neurological diseases

16:45 Anne Spurkland, Anatomisk institutt, UiO: Multiple sclerosis – new information from neuroimmunology

17:15 Ole Petter Ottersen/Erling Seeberg, CMBN: Concluding remarks

17:30 Course exam

Refreshments

Additional information

Godkjenninger: Valgfritt for alle spesialiteter.
Målgruppe: Doktorgradskandidater, forskere, leger under utdanning og spesialister generelt
Læringsmål: Kurset skal gi deltakerne en grunnleggende innsikt i den delen av molekylær medisin som omhandler nevrologiske lidelser og aldring
Innhold: Forskerkurset skal gi en innføring i nøkkelaspekter innen molekylær medisin med hovedvekt på patogenese og diagnostikk ved nevrologiske sykdommer og aldring. Hovedmålet er å øke forståelsen av hvordan nerveceller fungerer i den friske og syke hjerne. Temaer som vil bli addressert er neuro-imaging, patogenese ved nevrodegenerative lidelser, genomisk instabilitet og vedlikehold, cellulær overlevelse, hjerneødem, genetikk ved representative nevrologiske sykdommer, potensiale for stamcelleterapi, mikrobe-vertsinteraksjon, transmembran transport, synaptisk kommunikasjon og nevroimmunologi. Kurset vil fokusere på translasjonsrettet forskning og integrere basal og klinisk kunnskap om hvert enkelt tema. Konsekvenser for nye strategier for utvikling av nye strategier for diagnostikk og behandlingsregimer innen nevrologiske sykdommer vil bli diskutert.
Kursledelse: Tone Tønjum, Mikrobiologisk institutt, Rikshospitalet, Universitetet i Oslo og Jon Storm-Mathiesen, Anatomisk institutt, Universitetet i Oslo
Påmelding til: Den norske lægeforening, Kontor for legers videre- og etterutdanning, Postboks 1152 Sentrum, 0107 Oslo.
Påmelding E-post: koordinatorkontoret.oslo@legeforeningen.no
Påmeldingsfrist: 1. oktober 2004
Studiepoeng: 2,5
Antall deltakere: 150
Antall kurstimer: 19
Kursavgift: Kr. 300
Kurslitteratur: Litteratur utleveres og anbefales ved hver enkelt forelesning
Andre opplysninger: 1 times kursprøve blir avholdt umiddelbart etter kurset. Tildeling av kursbevis og studiepoeng er betinget av bestått kursprøve.