CMBN research seminar (forskerkurs):
Genome instability and neurologic disease
Thursday 22 April - Friday 23 April 2004
New auditorium 13 at Domus Medica, University of Oslo
Deadline for signing on the course: April 1st, 2004 to Den norske
lægeforening, email koordinatorkontoret.oslo@legeforeningen.no
Information on the course: Peder Heyerdahl Utne, email p.h.utne@basalmed.uio.no
Scope
The objective of the course is to highlight key aspects of DNA
damage and repair in the pathogenesis of neurologic diseases, and
to improve our understanding of how nerve cells communicate in
the healthy and diseased brain. Topics addressed will be relevant
for neurologic diseases, genome instability and maintenance, stem
cell biology, brain development, microbial model systems, synaptic
communication and informatics/bioinformatics. The new information
provided is aimed at building an innovative basis for the development
of new approaches for the treatment of brain disease and age-related
neurologic impairment.
Program
(Revised 27 February 2004.)
Thursday, April 22
09:30 Ole Petter Ottersen: Welcoming address
Introduction to genome instability and neurologic disease
09:35 Erling Seeberg: How do defects in DNA repair cause neurologic
disease and ageing?
09:50 Ole Petter Ottersen: Neurodegenerative disease – why
do neurons die?
10:30 Coffee break
Neurologic diseases
10:45 Karen Helene Ørstavik, Rikshospitalet: Epigenetic
mechanisms and neurologic disease
11:30 Petter Strømme, Ullevål University Hospital:
How mutations can cause X-linked mental retardation and epilepsy
12:00 Break
12:15 David Smith, Oxford, UK: On the role of homocysteine in
the development of Alzheimer’s disease
13:00 Lunch
DNA repair in neurologic disease
13:30 Arne Klungland: DNA repair defects: Cancer or neurologic
deficiency, or both?
14:00 Lars Eide: Mitochondrial (dys)function in Huntington’s
disease
Molecular aspects of synaptic transmission
14:30 Johan Storm: Regulation of synaptic efficacy by pre- and
postsynaptic potassium channels
15:00 Nils-Christian Danbolt: Neurotransmittor inactivation
15:30 Jon Storm-Mathisen: Providing the transmittor: molecular
analysis of synthesis, storage and metabolism
Friday, April 23
Neurodegenerative diseases
09:00 Agneta Nordberg, Karolinska Institute, Sweden: Functional
studies of cholinergic activity in normal and Alzheimer disease
states by imaging techniques
09:45 Lars Lannfelt, Karolinska Institute, Sweden: Genetics and
future treatment in Alzheimer’s disease (to be confirmed)
10:30 Coffee break
Genome instability and disease
10:45 Josef Jiricny, Molecular Cancer Institute,University of
Zurich, Switzerland: Mismatch repair defects in DNA damage signaling
and cancer
11:30 Lunch
Prokaryotic model systems
12:00 Michael Koomey: DNA rearrangements influencing host-pathogen
interactions
12:45 Tone Tønjum: Genome instability and neurodegenerative
diseases – what can we learn from prokaryotic model systems?
13:15 Break
Bioinformatics and neuroinformatics
13:30 Torbjørn Rognes: Bioinformatics tools for exploring
gene relationships relevant for neurologic disease
14:00 Jan Bjaalie: Original research data, protocols, and tools,
on the web. Will novel database strategies change the way we do
neuroscience?
14:30 Break
Neuro-therapeutic potential of stem cells
14:45 Stefan Krauss: Stem cells: overview of stem cell biology
and therapeutic potential
15:30 Course exam
16:30 Thank God it’s Friday: Servering
The program may be subject to minor changes.
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