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Guest lecture by Maiken Nedergaard

Astrocytes Alive!

Welcome to a CMBN lecture, Thursday June 26th 2008, at 13:00 in the lunch room (Anatomy Department).

Title: "Astrocytes Alive!"

By Professor Maiken Nedergaard


Professor Maiken Nedergaard (University of Rochester) is a leading scientist in the field of neuroscience. Her research has a strong focus on the biology of astrocytes and she has made seminal discoveries regarding the roles of astrocytes in the pathophysiology of epilepsy. Many of her breakthroughs have been based on in vivo analysis, using multiphoton laser microscopy. Nedergaard is also known for her analyses of mechanisms that underlie the regulation of blood flow in brain.

Oberheim NA, Tian GF, Han X, Peng W, Takano T, Ransom B, Nedergaard M.
Loss of astrocytic domain organization in the epileptic brain.
J Neurosci. 2008 Mar 26;28(13):3264-76.

Iadecola C, Nedergaard M.
Glial regulation of the cerebral microvasculature.
Nat Neurosci. 2007 Nov;10(11):1369-76.

Takano T, Tian GF, Peng W, Lou N, Lovatt D, Hansen AJ, Kasischke KA,
Nedergaard M.
Cortical spreading depression causes and coincides with tissue hypoxia.
Nat Neurosci. 2007 Jun;10(6):754-62. Epub 2007 Apr 29.

Ballabh P, Xu H, Hu F, Braun A, Smith K, Rivera A, Lou N, Ungvari Z, Goldman SA, Csiszar A, Nedergaard M.
Angiogenic inhibition reduces germinal matrix hemorrhage.
Nat Med. 2007 Apr;13(4):477-85. Epub 2007 Apr 1.

Liu QS, Xu Q, Kang J, Nedergaard M.
Astrocyte activation of presynaptic metabotropic glutamate receptors modulates hippocampal inhibitory synaptic transmission.
Neuron Glia Biol. 2004 Nov;1(4):307-316.

Wang X, Lou N, Xu Q, Tian GF, Peng WG, Han X, Kang J, Takano T, Nedergaard M.
Astrocytic Ca2+ signaling evoked by sensory stimulation in vivo.
Nat Neurosci. 2006 Jun;9(6):816-23. Epub 2006 May 14.

Takano T, Tian GF, Peng W, Lou N, Libionka W, Han X, Nedergaard M.
Astrocyte-mediated control of cerebral blood flow.
Nat Neurosci. 2006 Feb;9(2):260-7. Epub 2005 Dec 25.

Takano T, Kang J, Jaiswal JK, Simon SM, Lin JH, Yu Y, Li Y, Yang J, Dienel G, Zielke HR, Nedergaard M.
Receptor-mediated glutamate release from volume sensitive channels in astrocytes.
Proc Natl Acad Sci U S A. 2005 Nov 8;102(45):16466-71. Epub 2005 Oct 27.

Tian GF, Azmi H, Takano T, Xu Q, Peng W, Lin J, Oberheim N, Lou N, Wang X,Zielke HR, Kang J, Nedergaard M.
An astrocytic basis of epilepsy.
Nat Med. 2005 Sep;11(9):973-81. Epub 2005 Aug 14.

Wang X, Arcuino G, Takano T, Lin J, Peng WG, Wan P, Li P, Xu Q, Liu QS,
Goldman SA, Nedergaard M.
P2X7 receptor inhibition improves recovery after spinal cord injury.
Nat Med. 2004 Aug;10(8):821-7. Epub 2004 Jul 18.

Nedergaard M, Ransom B, Goldman SA.
New roles for astrocytes: redefining the functional architecture of the brain.
Trends Neurosci. 2003 Oct;26(10):523-30. Review.

Ransom B, Behar T, Nedergaard M.
New roles for astrocytes (stars at last).
Trends Neurosci. 2003 Oct;26(10):520-2. Review.

Nunes MC, Roy NS, Keyoung HM, Goodman RR, McKhann G 2nd, Jiang L, Kang J, Nedergaard M, Goldman SA.
Identification and isolation of multipotential neural progenitor cells from the subcortical white matter of the adult human brain.
Nat Med. 2003 Apr;9(4):439-47. Epub 2003 Mar 10.

Nedergaard M, Takano T, Hansen AJ.
Beyond the role of glutamate as a neurotransmitter.
Nat Rev Neurosci. 2002 Sep;3(9):748-55. Review.

Arcuino G, Lin JH, Takano T, Liu C, Jiang L, Gao Q, Kang J, Nedergaard M.
Intercellular calcium signaling mediated by point-source burst release of ATP.
Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9840-5. Epub 2002 Jul 3.


Centre for Molecular Biology and Neuroscience (CMBN)
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