Guest lecture by Paola Bezzi
Welcome to a CMBN lecture, Friday May 16th 2008, at 12:00 in the lunchroom (Anatomy Department).
Title:
"Fast sub-plasma membrane Ca2+ transients control exo-endocytosis
processes in astrocytes"
By Dr. Paola Bezzi
Dr Bezzi is working at the Department of Cell Biology and Morphology,
University of Lausanne. Her research has for several years focused on
release of glutamate from astrocytes. During the last years she has
especially been studying the the importance of the dynamics of Ca2+
signals for glutamate release from living astrocytes.
Selected papers:
Domercq M, Brambilla L, Pilati E, Marchaland J, Volterra A, Bezzi P.
(2006) P2Y1 receptor-evoked glutamate exocytosis from astrocytes:
control by tumor necrosis factor-alpha and prostaglandins. J Biol Chem.
281:30684-96.
Rossi D, Brambilla L, Valori CF, Crugnola A, Giaccone G, Capobianco R,
Mangieri M, Kingston AE, Bloc A, Bezzi P, Volterra A. (2005) Defective
tumor necrosis factor-alpha-dependent control of astrocyte glutamate
release in a transgenic mouse model of Alzheimer disease. J Biol Chem.
280:42088-96.
Bezzi P, Gundersen V, Galbete JL, Seifert G, Steinhäuser C, Pilati E,
Volterra A. (2004) Astrocytes contain a vesicular compartment that is
competent for regulated exocytosis of glutamate. Nat Neurosci. 7:613-20.
Bezzi P, Domercq M, Brambilla L, Galli R, Schols D, De Clercq E, Vescovi
A,Bagetta G, Kollias G, Meldolesi J, Volterra A. (2001) CXCR4-activated
astrocyte glutamate release via TNFalpha: amplification by microglia
triggers neurotoxicity. Nat Neurosci. 4:702-10.
Bezzi P, Carmignoto G, Pasti L, Vesce S, Rossi D, Rizzini BL, Pozzan T,
Volterra A. (1998) Prostaglandins stimulate calcium-dependent glutamate
release in astrocytes. Nature. 391:281-5.
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