Cortical development and cortical stem cells
The laboratory uses neural stem cell culture, transgenic model systems and retroviral vectors to study signalling pathways that are central in mouse cortical development and in particular in cortical stem cells. Some of the long term aims of the studies are (i) to contribute to the understanding of the mechanisms that control cortical development and evolution, (ii) to use the knowledge to grow neural stem cell populations of high purity and viability for therapeutic approaches and (iii) to study how neural stem cells can be activated in vivo .
Targeted repair in stem cells
The laboratory co-ordinates a EU network "Therapeutic in vivo DNA repair by site-specific double-strand breaks" that propose to develop a generally applicable technology that should allow high efficiency targeted gene conversion in vivo. The double strand breaks are created either by site-specific designer zinc finger endonucleases or triple helix forming oligonucleotides that are able to recognise and induce repair of specific mutations in the genome.
Additional members of the Network are Tony Cathomen (Charité – Universitätsmedizin Berlin, Germany), Klaus Schwarz (University Hospital, Ulm, Germany), Luis Serrano (Centre de regulacio Genomica, Barcelona, Spain), Tom Brown (University of Southampton, UK), Roland Kanaar (Erasmus medical center, Rotterdam, Netherlands), Bengt Norden (Chalmers, Gothenburg, Sweden) ATDbio Ltd. (Southampton, UK) and GeneArt AG (Regensburg, Germany).
Last uptdated 19.03. 2009