Laboratory of molecular neuroscience

Key publications and commentaries:

Bohr VA, Ottersen OP, Tonjum T (2007)
Genome instability and DNA repair in brain, ageing and neurological disease.
Neuroscience. Mar 30; [Epub ahead of print]

Eid T, Hammer J, Runden-Pran E, Roberg B, Thomas MJ, Osen K, Davanger S, Laake P, Torgner IA, Lee TS, Kim JH, Spencer DD, Ottersen OP, de Lanerolle NC (2007)
Increased expression of phosphate-activated glutaminase in hippocampal neurons in human mesial temporal lobe epilepsy.
Acta Neuropathol (Berl). Feb;113(2):137-52. Epub 2006 Nov 18.

Celsi F, Svedberg M, Unger C, Cotman CW, Carri MT, Ottersen OP, Nordberg A, Torp R (2007)
Beta-amyloid causes downregulation of calcineurin in neurons through induction of oxidative stress. Neurobiol Dis. Jan 25; [Epub ahead of print]

Michaluk P, Kolodziej L, Mioduszewska B, Wilczynski GM, Dzwonek J, Jaworski J, Gorecki DC, Ottersen OP, Kaczmarek L (2007)
Beta -dystroglycan as a target for MMP-9 in response to enhanced neuronal activity.
J Biol Chem. Apr 10; [Epub ahead of print]

Biskup S, Moore DJ, Celsi F, Higashi S, West AB, Andrabi SA, Kurkinen K, Yu SW, Savitt JM, Waldvogel HJ, Faull RL, Emson PC, Torp R, Ottersen OP, Dawson TM, Dawson VL (2006)
Localization of LRRK2 to membranous and vesicular structures in mammalian brain.
Ann Neurol. Nov 21;60(5):557-569 [Epub ahead of print]

Eid T, Hammer J, Runden-Pran E, Roberg B, Thomas MJ, Osen K, Davanger S, Laake P, Torgner IA, Lee TS, Kim JH, Spencer DD, Ottersen OP, de Lanerolle NC (2006)
Increased expression of phosphate-activated glutaminase in hippocampal neurons in human mesial temporal lobe epilepsy.
Acta Neuropathol (Berl). 2006 Nov 18; [Epub ahead of print]

Frydenlund DS, Bhardwaj A, Otsuka T, Mylonakou MN, Yasumura T, Davidson KG, Zeynalov E, Skare O, Laake P, Haug FM, Rash JE, Agre P, Ottersen OP, Amiry-Moghaddam M (2006)
Temporary loss of perivascular aquaporin-4 in neocortex after transient middle cerebral artery occlusion in mice.
Proc Natl Acad Sci U S A 2006 Aug 28; [Epub ahead of print]

Sailer CA, Kaufmann WA, Kogler M, Chen L, Sausbier U, Ottersen OP, Ruth P, Shipston MJ, Knaus HG (2006)
Immunolocalization of BK channels in hippocampal pyramidal neurons.
Eur J Neurosci 24(2):442-54

Puwarawuttipanit W, Bragg AD, Frydenlund DS, Mylonakou MN, Nagelhus EA, Peters MF, Kotchabhakdi N, Adams ME, Froehner SC, Haug FM, Ottersen OP, Amiry-Moghaddam M (2006)
Differential effect of alpha-syntrophin knockout on aquaporin-4 and Kir4.1 expression in retinal macroglial cells in mice.
Neuroscience 137(1):165-75

Bergersen LH, Thomas M, Johannsson E, Waerhaug O, Halestrap A, Andersen K, Sejersted OM, Ottersen OP (2006)
Cross-reinnervation changes the expression patterns of the monocarboxylate transporters 1 and 4: An experimental study in slow and fast rat skeletal muscle.
Neuroscience 138(4):1105-13

Warskulat U, Borsch E, Reinehr R, Heller-Stilb B, Monnighoff I, Buchczyk D, Donner M, Flogel U, Kappert G, Soboll S, Beer S, Pfeffer K, Marschall HU, Gabrielsen M, Amiry-Moghaddam M, Ottersen OP, Dienes HP, Haussinger D (2006)
Chronic liver disease is triggered by taurine transporter knockout in the mouse.
FASEB J 20(3):574-6

Rash JE, Davidson KG, Kamasawa N, Yasumura T, Kamasawa M, Zhang C, Michaels R, Restrepo D, Ottersen OP, Olson CO, Nagy JI (2006)
Ultrastructural localization of connexins (Cx36, Cx43, Cx45), glutamate receptors and aquaporin-4 in rodent olfactory mucosa, olfactory nerve and olfactory bulb.
J Neurocytol Sep;34(3-5):307-41

Bragg AD, Amiry-Moghaddam M, Ottersen OP, Adams ME, Froehner SC (2006)
Assembly of a perivascular astrocyte protein scaffold at the mammalian blood-brain barrier is dependent on alpha-syntrophin.
Glia 53(8):879-90

Amiry-Moghaddam M, Lindland H, Zelenin S, Roberg BA, Gundersen BB, Petersen P, Rinvik E, Torgner IA, Ottersen OP (2005)
Brain mitochondria contain aquaporin water channels: evidence for the expression of a short AQP9 isoform in the inner mitochondrial membrane.
FASEB J 19(11):1459-67

Runden-Pran E, Tanso R, Haug FM, Ottersen OP, Ring A (2005)
Neuroprotective effects of inhibiting N-methyl-D-aspartate receptors, P2X receptors and the mitogen-activated protein kinase cascade: a quantitative analysis in organotypical hippocampal slice cultures subjected to oxygen and glucose deprivation.
Neuroscience 136(3):795-810

Holen T, Moe SE, Sorbo JG, Meza TJ, Ottersen OP, Klungland A (2005)
Tolerated wobble mutations in siRNAs decrease specificity, but can enhance activity in vivo.
Nucleic Acids Res 33(15):4704-10

Zhang L, Shimoji M, Thomas B, Moore DJ, Yu SW, Marupudi NI, Torp R, Torgner IA, Ottersen OP, Dawson TM, Dawson VL (2005)
Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis.
Hum Mol Genet 14(14):2063-73

Nagelhus EA, Mathiisen TM, Bateman AC, Haug FM, Ottersen OP, Grubb JH, Waheed A, Sly WS (2005)
Carbonic anhydrase XIV is enriched in specific membrane domains of retinal pigment epithelium, Muller cells, and astrocytes.
Proc Natl Acad Sci U S A 102(22):8030-5

Ottersen OP (2005)
Neurobiology: sculpted by competition.
Nature 434(7036):969

Eid T, Lee TS, Thomas MJ, Amiry-Moghaddam M, Bjornsen LP, Spencer DD, Agre P, Ottersen OP, de Lanerolle NC (2005)
Loss of perivascular aquaporin 4 may underlie deficient water and K+ homeostasis in the human epileptogenic hippocampus.
Proc Natl Acad Sci U S A 102(4):1193-8 Epub 2005 Jan 18

Solbu TT, Boulland JL, Zahid W, Lyamouri Bredahl MK, Amiry-Moghaddam M, Storm-Mathisen J, Roberg BA, Chaudhry FA (2005)
Induction and targeting of the glutamine transporter SN1 to the basolateral membranes of cortical kidney tubule cells during chronic metabolic acidosis suggest a role in pH regulation.
J Am Soc Nephrol (4):869-77. Epub 2005 Feb 16

Bernard-Trifilo JA, Kramar EA, Torp R, Lin CY, Pineda EA, Lynch G, Gall CM (2005)
Integrin signaling cascades are operational in adult hippocampal synapses and modulate NMDA receptor physiology.
J Neurochem 93(4):834-49

Gabriele Nase, P. Johannes Helm, Trond Reppen, and Ole Petter Ottersen (2005)
A multiphoton laser scanning microscope setup for transcranial in vivo brain imaging on mice.
Rev Sci Instrum 76(12):123702

Amiry-Moghaddam M, Xue R, Haug FM, Neely JD, Bhardwaj A, Agre P, Adams ME, Froehner SC, Mori S, Ottersen OP (2004)
Alpha-syntrophin deletion removes the perivascular but not endothelial pool of aquaporin-4 at the blood-brain barrier and delays the development of brain edema in an experimental model of acute hyponatremia.
FASEB J 18(3): 542-4

Eid T, Thomas MJ, Spencer DD, Runden-Pran E, Lai JC, Malthankar GV, Kim JH, Danbolt NC, Ottersen OP, de Lanerolle NC (2004)
Loss of glutamine synthetase in the human epileptogenic hippocampus: possible mechanism for raised extracellular glutamate in mesial temporal lobe epilepsy.
Lancet 63(9402):28-37

Amiry-Moghaddam M, Ottersen OP (2003)
The molecular basis of water transport in the brain.
Nature Rev Neurosci 4(12):991-1001

Amiry-Moghaddam M, Williamson A, Palomba M, Eid T, de Lanerolle NC, Nagelhus, EA, Adams ME, Froehner SC, Agre P, Ottersen OP (2003)
Delayed K+ clearance associated with aquaporin-4 mislocalization: phenotypic defects in brains of alpha-syntrophin-null mice.
Proc Natl Acad Sci U S A 100(23):13615-20

Amiry-Moghaddam M, Otsuka T, Hurn PD, Traystman RJ, Haug FM, Froehner SC, Adams ME, Neely JD, Agre P, Ottersen OP, Bhardwaj A (2003)
An alpha-syntrophin-dependent pool of AQP4 in astroglial end-feet confers bidirectional water flow between blood and brain.
Proc Natl Acad Sci U S A 100(4):2106-11

Ottersen OP, Helm PJ (2002)
How hardwired is the brain?
Nature 420(6917):751-2.

Neely JD, Amiry-Moghaddam M, Ottersen OP, Froehner SC, Agre P, Adams ME (2001)
Syntrophin-dependent expression and localization of Aquaporin-4 water channel protein.
Proc Natl Acad Sci U S A 98(24):14108-13

Didier A, Carleton A, Bjaalie JG, Vincent JD, Ottersen OP, Storm-Mathisen J, Lledo PM (2001)
A dendrodendritic reciprocal synapse provides a recurrent excitatory connection in the olfactory bulb.
Proc Natl Acad Sci U S A 98(11):6441-6

Takumi Y, Ramirez-Leon V, Laake P, Rinvik E, Ottersen OP (1999)
Different modes of expression of AMPA and NMDA receptors in hippocampal synapses.
Nature Neurosci 2(7):618-24

Snyder GL, Fisone G, Morino P, Gundersen V, Ottersen OP, Hokfelt T, Greengard P (1993)
Regulation by the neuropeptide cholecystokinin (CCK-8S) of protein phosphorylation in the neostriatum.
Proc Natl Acad Sci U S A 90 (23):11277-81

Ehinger B, Ottersen OP, Storm-Mathisen J, Dowling JE (1988)
Bipolar cells in the turtle retina are strongly immunoreactive for glutamate.
Proc Natl Acad Sci U S A 85(21):8321-5

Dale N, Ottersen OP, Roberts A, Storm-Mathisen J (1986)
Inhibitory neurones of a motor pattern generator in Xenopus revealed by antibodies to glycine.
Nature 324(6094):255-7

Storm-Mathisen J, Leknes AK, Bore AT, Vaaland JL, Edminson P, Haug FM, Ottersen OP (1983)
First visualization of glutamate and GABA in neurones by immunocytochemistry.
Nature 301(5900):517-20