Centre for the Biology of Memory

Summary of activity

The scientific goal of the Centre is to understand the biological processes responsible for memory and spatial representation and to use these as tools to understanding cortical network dynamics more generally. To reach this aim, the Centre brings together internationally leading neuroscientists in a geographically localised Centre associated with NTNU in Trondheim, Norway.

Contact information

Centre for the Biology of Memory, Faculty of Medicine, NTNU, Trondheim.
See www.cbm.ntnu.no

Senior personnel

professor May-Britt Moser (co-director)
professor Edvard Moser (director)
professor Menno Witter
Dr. Stefan Leutgeb

6 visiting professors in part time positions:
Bruce McNaughton, Univ. of Arizona
Richard Morris, Univ. Edinburgh
Carol Barnes, Univ. Arizona
Alessandro Treves, SISSA, Trieste
Randolf Menzel, Free Univ Berlin
Ole Paulsen, Univ Oxford

Personnel's neuroinformatic skills/background

Alessandro Treves (computational)
Bruce McNaughton (experimental-computational interface)
Stefan Leutgeb, May-Britt Moser and Edvard Moser (experimental-computational interface)
Menno Witter (imaging, visualization)

Experimental tools

Neurophysiological high-density multichannel recording.
Confocal microscopy.
Viral transfection technology.

Key publications

  • Fyhn, M., Hafting, T., Treves, A., Moser, M.-B. and Moser, E.I. (2007). Hippocampal remapping and grid realignment in entorhinal cortex. Nature, 446, 190-194.
  • Leutgeb, J.K., Leutgeb, S., Moser, M.-B., and Moser, E.I. (2007). Pattern separation in dentate gyrus and CA3 of the hippocampus. Science , 315, 961-966.
  • Witter, M.P. and Moser, E.I. (2006). Spatial representation and the architecture of the entorhinal cortex. Trends in Neurosciences, 29, 671-678.
  • McNaughton, B.L., Battaglia, F.P., Jensen, O., Moser, E.I., and Moser, M.-B. (2006). Path-integration and the neural basis of the ‘cognitive map’. Nature Reviews Neuroscience, 7, 663-678.
  • Sargolini, F., Fyhn, M., Hafting, T., McNaughton, B.L., Witter, M.P., Moser, M.-B., and Moser, E.I. (2006). Conjunctive representation of position, direction and velocity in entorhinal cortex. Science, 312, 754-758.
  • Colgin, L.L, and Moser, E.I. (2006). Rewinding the memory record. Nature, 440, 615-617.
  • Leutgeb, J.K., Leutgeb, S., Treves, A., Meyer, R., Barnes, C.A., McNaughton, B.L., Moser, M.-B., and Moser, E.I. (2005). Progressive transformation of hippocampal neuronal representations in ‘morphed’ environments. Neuron, 20, 345-358.
  • Hafting, T., Fyhn, M., Molden, S., Moser, M.-B., and Moser, E.I. (2005). Microstructure of a spatial map in the entorhinal cortex. Nature, 436, 801-806.
  • Leutgeb, S., Leutgeb, J.K., Barnes, C.A., Moser, E.I., McNaughton, B.L., and Moser, M.-B (2005). Independent codes for spatial and episodic memory in the hippocampus. Science, 309, 619-623.
  • Steffenach, H.-A., Witter, M.P., Moser, M.-B., and Moser, E.I. (2005). Spatial memory in the rat requires the dorsolateral band of the entorhinal cortex. Neuron, 45, 301-313.
  • Leutgeb, S., Leutgeb, J.K., Treves, A., Moser, M.-B. and Moser, E.I. (2004). Distinct ensemble codes in hippocampal areas CA3 and CA1. Science 305, 1295-1298.
  • Fyhn, M., Molden, S., Witter, M.P., Moser, E.I. and Moser, M.-B. (2004). Spatial representation in the entorhinal cortex. Science, 305, 1258-1264.
  • Moser, E.I. (2003). Interneurons take charge. Nature, 421, 797-799.
  • Kjelstrup, K.G., Tuvnes, F.A., Steffenach, H.-A., Murison, R., Moser, E.I., Moser, M.-B. (2002). Reduced fear expression after lesions of the ventral hippocampus. Proceedings of the National Academy of the Sciences USA, 99, 10825-10830.
  • Fyhn, M., Molden, S., Hollup, S.A., Moser, M.-B. & Moser, E.I. (2002). Hippocampal neurons responding to first-time dislocation of a target object. Neuron, 35, 555-566.
  • Brun, V.H., Otnæss, M.K., Molden, S., Steffenach, H.-A., Witter, M.P., Moser, M.-B., Moser, E.I. (2002). Place cells and place representation maintained by direct entorhinal-hippocampal circuitry. Science, 296, 2089-2284.
  • Steffenach, H.-A., Sloviter, R.S., Moser, E.I. & Moser, M.-B. (2002). Impaired retention of spatial memory after transection of longitudinally-oriented axons of hippocampal CA3 pyramidal cells. Proceedings of the National Academy of the Sciences USA, 99, 3194-3198.